Abstract: Solar activity is an important factor driving the formation of the Earth’s climate, and is closely linked with global climate change. Studies found that the response of the Earth’s climate change to solar activities is inhomogeneous in space. Weather and climate of certain regions on Earth are found more sensitive to solar activities. In this paper, we concentrate on sensitive responses to solar activity in the Arctic-North Atlantic, tropical and monsoon regions. The fact that solar activities have a great influence on polar-North Atlantic regions on different time scales is presented, and we believe that cloud microphysical processes and the stratosphere-troposphere coupling play an important role in modulating relationships as aforementioned. Then we reviewed significant solar signals in convection, sea surface temperature and the ENSO cycle in the tropics.The responses of monsoon regions, especially the Asian monsoon, to solar activities are summed up, the response being particularly active in the marginal areas of monsoon. Finally, scientific issues which need to be focused on are put forward for future investigation on the regions with sensitive signals of solar activities in weather and climate.