Abstract: Regional automatic weather stations play an important role in meteorological early warning, environmental monitoring, and utilization of climatic resources, climate change response and ecological civilization construction. Checking and calibrating the observation instruments is crucial to ensuring high accuracy and reliability of the observation data of regional automatic weather stations (AWSs). According to the principles and characteristics of regional AWSs and the status quo of regional AWS calibration, the existing problems of regional AWS calibration are identified. Then, the key technologies of regional AWS calibration automation, informatization, standard comparisons, and remote online calibration are studied in detail in terms of their principles and implementation of key technologies. The key technologies of regional AWS calibration proposed in this paper provide a more comprehensive and advanced solution for the metrological calibration of regional AWS, thus effectively guaranteeing the accuracy and reliability of the observation data from regional AWSs.