Abstract: Based on MOD17A3H Net primary productivity of vegetation data, climate data and land use data, using GIS analysis and statistical analysis methods, the spatial and temporal characteristics of forest vegetation NPP in Guangdong Province from 2005 to 2015 were analyzed. The results show that: 1) both the annual mean value of NPP of forest vegetation and the annual total NPP of Guangdong Province had a trend of fluctuation and increased from 2005 to 2015; 2) in terms of spatial distribution, NPP of forest vegetation in Guangdong province had spatial heterogeneity from 2005 to 2015. The annual NPP mean value was the highest in Chaozhou and the lowest in Zhongshan and Zhanjiang; 3) 15.93% of NPP in Guangdong province showed no significant change, while 63.45% showed significant increased and 20.62% showed significant decrease, respectively. From 2005 to 2015, NPP in Guangdong province decreased significantly mainly in Qingyuan, Shaoguan, Heyuan, Meizhou and Zhanjiang in the north of Guangdong province, while NPP increased significantly in Maoming, Yangjiang and Yunfu in the south of Guangdong province; 4) the effect of temperature and precipitation on NPP of forest vegetation showed obvious spatial differentiation.